The MultiSyn is the most compact, versatile and easy to use disposable cassette Theranostic Plus Synthesizer.
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Product Description
One synthesizer for all your radiochemistry needs
Standardize and simplify your labs radiochemistry requirements with the one versatile synthesizer. By simply changing the hardware cassette, you can easily switch to another radiosynthesis without any cross-contamination.
Ga-68 Versatility
Compatible with all Ga-68 Generators.
The MultiSyn is compatible with all commercial Ga-68 generators.
The MultiSyn has a built-in force limiting syringe drive for generator elution and can perform no pre-purification, as well as cationic or anionic pre-purification of the generators eluate.
Direct Elution Labelling
The simplest 68Ga synthesis method involves direct labelling of the generators eluate.
This method reduces synthesis time and simplifies system setup.
Generator Pre-purification
Certain reactions require reduction of the acid concentration of the generator eluate and or purification of metal impurities (such as 68Ge) from the eluate to improve reaction conditions.
This is easily accomplished with generator pre-purification and involves trapping the generator eluate onto a purification cartridge and subsequent elution to the reactor with a >99% trap and release efficiency of 68Ga.
Multiple Generator Elution
The MultiSyn can be used to elute multiple generators to increase final radiotracer activity
Lutetium-177 & Actinium-225
Theranostic capabilities
The MultiSyn enables the radiochemist to easily synthesize Theranostic agents such as 177Lu-PSMA and 177Lu- DOTATATE with high isotope recovery.
Copper-64 & 67
Novel Applications
Easily develop novel methods such as copper radioisotope radiolabeling with the MultiSyn for bot PET imaging and Theranostic applications.
“Results show that a consistent, efficient and reliable automated method for the manufacture of 64Cu-SARTATE and 67Cu-SARTATE using the MultiSyn radiosynthesiser has been developed, which results in a high yield of product suitable for use in clinical trials, that can be compliant to GMP requirements” …… Clarity Pharmaceuticals
Fully automated synthesis of [64&67Cu] SARTATE on the MultiSyn
Zirconium-89
Monoclonal antibody radiolabeling
Fully automate 89Zr monoclonal antibody radiolabeling using the MultiSyn.
Typical fully automated synthesis process involves:
1. Automated cartridge conditioning
2. 89Zr Neutralization
3. Radiolabelling
4. Purification using PD-10 cartridge
Cassettes available.
Automated radiosynthesis of [89Zr]Zr-DFOSq-Durvalumab on the iPHASE MultiSyn module
Flourine-18
Not Just For Radiometals
In addition to the radiometal radiolabeling capabilities of the MultiSyn, 18F compounds can also be synthesized such as:
- 18F-FDG
- 18F-NaF
- 18F-PSMA
- More coming soon
Exceptional Performance
Optimized Synthesis Recipes
- 68Ga PSMA 81%
- 68Ga DOTATATE 75%
- 177Lu PSMA 92%
- 177Lu DOTATATE 92%
- 64, 67Cu SARTATE 65%
- 89Zr Durvalumab 75%
- 89Zr Crefmirlimab Berdoxam 76%
- 18F FDG ≥ 70%
External Control Electronics
Eliminate Radiation Damage
The MultiSyn’s PLC (programmable logic controller) electronics are housed in an external enclosure located outside of the Hot Cell.
This eliminates the possibility of damage to the electronic components due to high radiation fields thereby significantly increasing system reliability.
Compact Dimensions
Easily Install Multiple Synthesizers In One Hot Cell
